Rosie O'Donnell appeared in the episode "Trapper Keeper". She is Filmore's aunt. She stalls the class president election in Filmore's kindergarten class by relentlessly trying to make sure that the votes are counted correctly so that Ike, Filmore's opponent in the election, can't win by cheating (like George W. Bush did in her opinion)
After being expelled from the class room by Mr. Garrison, she helps to unwittingly defeat the evil Trapper Keeper by annoying it, being absorbed, and then half dissolved inside it, before causing it indigestion.
In Principal Victoria's office, there is a photo of her and Rosie.
She is very obese, even having a double chin. She also has various facial wrinkles. She wears a hot-pink button-up shirt and dark blue pants. People mistake her for the blob trapper keeper.