John F. Kennedy was seen along with his son, John F. Kennedy Jr., as a resident of Hell during the song, "Christmas Time in Hell", in "Mr. Hankey's Christmas Classics". His brother, Ted Kennedy, later appeared in "Dead Celebrities". Kennedy's assassination was parodied in the episode, "Weight Gain 4000", in which Mr. Garrison attempts to shoot Kathie Lee Gifford from the book depository window in the same fashion as Oswald.
He appeared with a photo-realistic head, much like Saddam Hussein. His skin was gray due to his head being taken from a black and white photo. He wore a gray, long-sleeve shirt and brown pants.