Sharon invites a Jersey family, the Giudicies, into their home for dinner. The Jersey woman, Teresa Giudice from the Real Housewives of New Jersey, becomes very obnoxious and starts to insult Sharon and her friends, leading Sharon to calmly insult her. In response, Teresa goes crazy, screams obscenities at Sharon and flips the dinner table, but turns out completely fine after being calmed down by her husband Joe. Soon after, many people from New Jersey move into South Park and everyone starts to get annoyed with them. Randy calls a meeting at the Park County Community Center, where he reveals that New Jersey is trying to take over the country and already has everything east of the Rocky Mountains, with all of Colorado in danger of becoming "West Jersey." Meanwhile, Sheila reveals that she is from New Jersey, and that Kyle was in fact conceived and briefly carried in Newark; the Broflovskis moved away two months into the pregnancy. Kyle, seemingly unable to control his actions, begins to shave and grease his bushy Jewfro into a style similar to those worn by the Jerseyites. He is even more shocked to find Sheila now fully decked out in this fashion. Whenever either of them is around New Jersey influences, she says, they will start to exhibit the same behavior.
Cartman's usual distrust of Kyle grows even stronger, since Kyle is now the "three J's" - Jewish, Jersey, and Ginger. Stan and Kenny, while also startled, do not react the same way. Kyle then pushes Cartman against a tree and threatens him, leading Cartman to cry over minor scrapes on his head. The townspeople have begun trying to drive the Jerseyites out, but in a bar they encounter a sex crazed Snooki. After it escapes, Randy pleads for help from California Governor Arnold Schwarzenegger, who tells him that the state cannot provide any assistance due to budget problems and general lack of concern (since Utah and Nevada Stand between California and the invasion). In desperation, Randy videotapes a request for help from Al-Qaeda and sends it to Osama bin Laden.
As the townspeople arm themselves and barricade the streets to stave off the invasion, Cartman asks Kyle to meet him at the Sizzler, with the intent of locking him in the meat freezer so he cannot help the Jerseyites. Once Cartman opens the freezer, the Snooki springs out and attempts to rape him and DogPoo Petuski. Kyle now fully transforms into a "Guido", complete with rings and gold neck chain and calling himself "Kyley-B," and proceeds to verbally and physically abuse the Snooki until it flees the restaurant. In the streets, the townspeople hold off the hordes of Jerseyites until the ammunition runs out; as the invaders are nearing the barricades, a fleet of Al-Qaeda suicide pilots flies in and crashes into the ground, killing them all. With the Jerseyites defeated, Cartman tells Kyle - "You're a monster, but you're my little monster" - and Bin Laden is killed by a Special Forces commando during a celebration held in his honor, with Randy exclaiming, "We got him!", a running joke through the series, and has been said various times when Bin Laden was killed on the show.