Ween performed the song "The Rainbow" on Chef Aid: The South Park Album. They also appeared in the accompanying mockumentary, Chef Aid: Behind the Menu, in which they talked about Chef's influence on their career.
- Trey Parker and Matt Stone directed a music video for the song "Even if You Don't" from the White Pepper album.
- Trey and Matt's band DVDA was the opening band for Ween on several occasions during 1999 through 2000 era.
- On March 16, 2022, it was announced that Ween (along with Trey, Matt, and PRIMUS) will be performing for the South Park: The 25th Anniversary Concert on August 10, 2022.
- "Comedy Central announces “South Park: The 25th Anniversary Concert” at Red Rocks Park". South Park Studios (March 17, 2022).