The Talk 2: The Gendering is a story mission in the video game, "South Park: The Fractured But Whole".
Plot details follow.
Head to the school (remember there’s a fast travel point right in front of it) and head inside.
There's a stream of electrified water blocking the way to Mr. Mackey's office. First, use Snap N Pops to knock the speaker down on the sixth grader’s head, revealing a switch behind him.
Then, use Time Fart: Pause to safely cross the water and pull the switch to deactivate the electricity.
Now head inside to talk to Mr. Mackey to really pin down your gender and sexuality preferences.
After that, go outside, where you’ll be attacked by the Hillbilly Brigade, regardless of your gender and sexuality.
Once you defeat them, continue on to Operation: Blind Justice.