The Talk is a story mission in the video game, "South Park: The Fractured But Whole".
Plot details follow.
From the church, head left then take the path south. Punch the snow man in front of South Park Elementary to get an Arcane Hat. Then, activate the Fast Travel point to the right before heading inside.
Note: Once inside, take Selfies with Annie and Ashley next to the stairs. Mr. Adler is on the left will, and will only take a Selfie with you if you "stop screwing around." Just don't press any buttons for a few seconds after you request a Selfie from him.
Head in through the hall and enter the Counselor's office to find Mr. Mackey. Here, you can choose your Sex/Gender. You can actually change it whenever you want, too!
Note: Before leaving the school, make sure to loot the gymnasium, where there's another piece of Creek Yaoi Art.