The Chains of Super Craig is a story mission in South Park: The Fractured But Whole.
Plot details follow.
The Coon orders you to check on Super Craig because he hasn't checked in for his superhero duty yet. Once you confront Super Craig, he will tell you he isn't doing anything heroic until he finds his guinea pig, Stripe; assist Super Craig in finding him.
From Kyle's House, head to the left to make it to the other side of town.
Once you reach the next block of houses, you will run into Bartles, a Sixth Grader, who is bullying Peter Mullen. If you had completed Alternate Universes Collide, you will have Human Kite by your side, and you should have no problem defeating him.
After beating Bartles, take a Selfie with Peter Mullen (this is a missable follower, he will not appear again once you leave) and loot Jimmy's House while you are here in order to find a costume and a few other items. Jimmy's parents are inside but will only take a Selfie with you on the second day after you have helped Jimmy.
Now continue to the left to find Craig's House.
Note: You will pass Henrietta's House, but you cannot do anything of interest here just yet, so skip it for now.
In the basement, pick up a box of Snap N Pops. You will get a new ability: Snap N Pops, which will now let you blast and knock things down. This can be used with Left Mouse (PC)/'X' (Xbox)/'Square Button' (PS4) while in Inspection Mode.
Throw the Snap N Pops at the pipe twice. Stripe will fall to the ground, before running on top of a cabinet to the left. Use the Snap N Pops on the box of firecrackers next to it to set off another explosion, Stripe will run behind a basket to the right of the basement. Pull the basket and Stripe will once again make its way out, into a small vent next to Craig. Eventually, you will need to fart in the vent, which will cause Stripe to come out, disoriented, and be safely put back in his enclosure. Craig will thank you (and your "sickening asshole"), and joins you as a combat ally.
Outside Craig's House, punch a pile of snow to the left of it to reveal a Divine Amplifier you can pick up.
Note: With the Snap N Pops unlocked, you can now head back to Henrietta's House to complete a small task to get Costumes. Grab Henrietta's Tome from Bradley's room, then talk to Michael. Light all the candles in the room with the Snap N Pops to summon a chest with a few costume pieces. You may also take a selfie with all the four goth kids.
Once you have finished looting and exploring, head back to the Coon Lair to continue the story with the next mission, Birth of a Coon Friend (or Alternate Universes Collide if you have not done so).