The South Park Animal Shelter appeared in Season Eight episode "Good Times with Weapons".
Background[]
After an incident where a shuriken gets lodged into Butters' left eye, the boys tries to cover it up by dressing Butters as a dog. Butters later escaped from the boys and make his way to the hospital, but his disguise fooled the doctors and he was instead sent to the local animal shelter.
While in the shelter, Butters was subjected to urination and defection from other dogs. The veterinarian attempted to put down Butters, but finds that Butters had already escaped, before deciding to take the syringe onto another dog instead.
Appearance[]
The animal shelter is a small teal building with a sheltered backyard. Its interior has a reception counter and a few holding rooms, one for each type of animal.