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Season Twenty | Season Twenty-One | Season Twenty-Two | 
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- Main article: List of Episodes
Officially announced on July 8, 2015[1], Season Twenty-One premiered on September 13, 2017. It dropped the serialized format used in the previous three seasons.
Episodes
| Screenshot | Title | Air Date | Code | # |
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"White People Renovating Houses" | September 13, 2017 | 2101 | 278 |
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Randy comes to grips with what it means to be white in today’s society. | ||||
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"Put It Down" | September 20, 2017 | 2102 | 279 |
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When Tweek is caught in the middle of a petty conflict, it drives his relationship with Craig to the brink. | ||||
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"Holiday Special" | September 27, 2017 | 2103 | 280 |
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In a return to form, a forbidden love story between a white man and a Native American man unfolds. | ||||
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"Franchise Prequel" | October 11, 2017 | 2104 | 281 |
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Facebook is the ultimate weapon for Professor Chaos. | ||||
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"Hummels & Heroin" | October 18, 2017 | 2105 | 282 |
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Beloved entertainers are being cut down in their prime due to massive overdoses of opiates. Stan is about to be exposed as the source of the illegal drugs. | ||||
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"Sons A Witches" | October 25, 2017 | 2106 | 283 |
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At the annual Halloween get together, a witch casts a spell that terrorizes everyone in South Park. | ||||
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"Doubling Down" | November 8, 2017 | 2107 | 284 |
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Kyle is playing with fire when he gets in the middle of Cartman and Heidi’s relationship. | ||||
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"Moss Piglets" | November 15, 2017 | 2108 | 285 |
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Jimmy and Timmy’s experiment could win them first prize in the annual science fair. | ||||
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"SUPER HARD PCness" | November 29, 2017 | 2109 | 286 |
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It’s never been more challenging to be a PC Principal. | ||||
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"Splatty Tomato" | December 6, 2017 | 2110 | 287 |
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The children of South Park claim to have seen Mr. Garrison lurking around town. The townspeople are angry that the President is scaring their children. | ||||
| Season Twenty-One | ||||