For all episodes see List of Episodes.
Season Four began on April 5, 2000. It contained seventeen episodes where the first half aired during spring and early summer and the second half airing in the fall. It ended on December 20, 2000.
| Screenshot | Title | Original airdate | Production code | |
|---|---|---|---|---|
| File:402 cartfairy.gif | "The Tooth Fairy Tats 2000" | April 5, 2000 | 402 | 49 |
| The boys plan to get rich off of a scheme involving the tooth fairy. | ||||
| File:SouthPark401.gif | "Cartman's Silly Hate Crime 2000" | April 12, 2000 | 401 | 50 |
| Cartman is imprisoned after committing a hate crime against Token (hitting him with a stone). | ||||
| File:SouthPark404.gif | "Timmy 2000" | April 19, 2000 | 404 | 51 |
| All the kids in South Park get mistakenly diagnosed with Attention-Deficit Disorder (ADD). Timmy joins a rock band. | ||||
| File:403 quint tv.gif | "Quintuplets 2000" | April 26, 2000 | 403 | 52 |
| A family of quintuplets attracts media. | ||||
| File:SouthPark406.gif | "Cartman Joins NAMBLA" | June 21, 2000 | 406 | 53 |
| Cartman joins a club in search of more mature friends. Kenny tries to stop his parents from having another baby. | ||||
| File:SouthPark407.gif | "Cherokee Hair Tampons" | June 28, 2000 | 407 | 54 |
| Stan must get Cartman to donate one of his kidneys to save Kyle's life. | ||||
| File:408 preburnin.gif | "Chef Goes Nanners" | July 5, 2000 | 408 | 55 |
| Chef is at odds with the town over the South Park flag. Wendy gets a crush on Cartman. | ||||
| File:409 fingerbanglive.gif | "Something You Can Do with Your Finger" | July 12, 2000 | 409 | 56 |
| The boys form a boy band, to which Stan's father Randy, objects. | ||||
| File:410 saddam and dinner.gif | "Do the Handicapped Go to Hell?" | July 19, 2000 | 410 | 57 |
| The boys question whether the handicapped or Jews go to heaven; Saddam Hussein returns to hell, leading to an awkward reunion with Satan. | ||||
| File:411 church building.gif | "Probably" | July 26, 2000 | 411 | 58 |
| Cartman and the boys start their own church against the wishes of their parents; Satan must choose between two lovers. | ||||
| File:412 newteach.gif | "4th Grade" | November 8, 2000 | 412 | 59 |
| The boys enter fourth grade, where they have a new teacher, Ms. Choksondik; Mr. Garrison finally faces the fact that he is homosexual. | ||||
|
"Trapper Keeper" | November 15, 2000 | 413 | 60 |
| A man from the future wants Cartman's trapper keeper; Mr. Garrison's kindergarten class holds an election with confusing results. | ||||
|
"Helen Keller! The Musical" | November 22, 2000 | 414 | 61 |
| Timmy must find a live turkey for the Thanksgiving play. | ||||
|
"Pip" | November 29, 2000 | 405 | 62 |
| A retelling of Charles Dickens' "Great Expectations" starring Pip, with Malcolm McDowell narrating. | ||||
| File:415 fat talk.gif | "Fat Camp" | December 6, 2000 | 415 | 63 |
| Cartman is sent to a weight loss camp; Kenny is paid to do numerous stunts. | ||||
| File:416 mayor cartman.gif | "The Wacky Molestation Adventure" | December 13, 2000 | 416 | 64 |
| The boys, angry at their parents, send them to jail after saying they were "molestered", leaving the town to the children. | ||||
| File:417 hankies22.gif | "A Very Crappy Christmas" | December 20, 2000 | 417 | 65 |
| Kyle is upset over the fact that Mr. Hankey is too busy with his family to spread holiday cheer. | ||||
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[[Season Three]] | Season Four | [[Season Five]] | 
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