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Season Four | Season Five | Season Six | 
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- Main article: List of Episodes
Season Five began on June 20, 2001. It contained fourteen episodes where the first half aired during the summer and the second half airing near winter. It finished on December 12, 2001.
The season continues with the "4th Grade" opening from last season. It would be the last season to air the opening until it was replaced with a country-style opening with new animation in Season Six. The season features the premier of two new characters, Jimmy Valmer and Towelie. The season also features the "permanent" death of Kenny McCormick in "Kenny Dies" and the preparation of Butters Stotch becoming a major character in the finale episode, "Butters' Very Own Episode".
This is the first season not to feature a Christmas episode.
This season contains two of the episodes considered the most dramatic in the series, "Cartmanland" and "Kenny Dies", which depict Kyle becoming deeply depressed, let down, and giving in to an illness, nearly killing him, and Kenny developing a muscular disease, forcing his friends to cope with his approaching, "real" death.
Episodes
| Screenshot | Title | Air Date | Code | # |
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"It Hits the Fan" | June 20, 2001 | 502 | 66 |
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The boys and Chef must stop the world from chanting the curse word "shit" because when spoken it causes people to "puke their own guts out". | ||||
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"Cripple Fight" | June 27, 2001 | 503 | 67 |
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Big Gay Al becomes the boys' scoutmaster and a fight ensues between two handicapped children, Jimmy Swanson and Timmy. | ||||
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"Super Best Friends" | July 4, 2001 | 504 | 68 |
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A cult comes to South Park and it is up to Stan, Jesus and his super hero comrades to save the world. | ||||
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"Scott Tenorman Must Die" | July 11, 2001 | 501 | 69 |
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Cartman repeatedly tries to take revenge on an 8th/9th grader who keeps making fun of him. | ||||
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"Terrance and Phillip: Behind the Blow" | July 18, 2001 | 505 | 70 |
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The boys try to reunite Terrance and Phillip who are feuding so they can perform at an Earth Day assembly. | ||||
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"Cartmanland" | July 25, 2001 | 506 | 71 |
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Kyle develops a deadly hemorrhoid and begins to lose his faith in God when Cartman inherits $1 million from his grandmother, which he uses to buy his own amusement park. | ||||
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"Proper Condom Use" | August 1, 2001 | 507 | 72 |
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The school is forced to teach sex education to the students at a younger age after the boys are found "milking" dogs. | ||||
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"Towelie" | August 8, 2001 | 508 | 73 |
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In order to get their video game console back, the boys must bring a talking towel to the government. | ||||
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"Osama bin Laden Has Farty Pants" | November 7, 2001 | 509 | 74 |
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The boys go to Afghanistan to return a goat given as a gift. | ||||
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"How to Eat with Your Butt" | November 14, 2001 | 510 | 75 |
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Cartman puts Kenny's picture on a milk carton which brings a family from another state looking for him. | ||||
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"The Entity" | November 21, 2001 | 511 | 76 |
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Kyle's cousin, who is also named Kyle, comes to stay in South Park.;Mr. Garrison, tired of the airlines, decides to invent his own vehicle. | ||||
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"Here Comes the Neighborhood" | November 28, 2001 | 512 | 77 |
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Token is tired of being teased for being rich, and he brings wealthier families to South Park. | ||||
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"Kenny Dies" | December 5, 2001 | 513 | 78 |
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Kenny succumbs to an illness; Cartman acquires stem cells for research. | ||||
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"Butters' Very Own Episode" | December 12, 2001 | 514 | 79 |
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Butters goes on a chase to find out what his father bought his mother for their anniversary. | ||||
| Season Five | ||||