Cartman comes up with a plan to get rid of Heidi by having Stan and Kyle go inside a Ross Dress for Less and plant explosives that would get her killed. Later on, the police get a call about the bad witch, Chip Duncan, who had kidnapped several children, being at Ross Dress for Less, however the rest of the witches believe that Stephen Stotch was the one who kidnapped the children.
Ross Dress for Less is apparently the creepiest place in South Park, according to Cartman.
The store makes a cameo in South Park: Post Covid. It is renamed to Ross Dress for Less Plus, having added the "Plus" suffix like many other locations.