- Professor Chaos - Butters' supervillain alter-ego.
- "Professor Chaos" - A Season Six episode focusing on the creation of Professor Chaos.
- Professor Lamont - Meme expert who appeared in "Faith Hilling".
- Professor Teabag - Professor of religious studies who appeared in "Fantastic Easter Special".
- Professor Chaos (Phone Destroyer) - A Superheroes card in South Park: Phone Destroyer.
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