The name Nelson can refer to a number of South Park characters, listed below:
- Allie Nelson - A student at South Park Elementary.
- Dr. David Nelson - A man with dwarfism who appeared in "With Apologies to Jesse Jackson".
- Gary Nelson - A worker at Airport Hilton.
- Gary Nelson (Ginger Kid) - Hallway monitor who appeared in "Ginger Kids" and South Park: The Stick of Truth.
- Lieutenant Nelson - A negotiator in "A Million Little Fibers".
- Liza Nelson - Margaret Nelson's daughter.
- Margaret Nelson - The fourth grade teacher who first appeared in "The City Part of Town".
- Mr. Nelson - Randy's boss who appeared in "Goobacks".
- Mrs. Nelson ("The Losing Edge") - Wife of Tom Nelson.
- Nelson Brown - A member of the Park County Pee-Wee Hockey Team.
- Nelson ("The Snuke") - A Secret Service Agent who appears in "The Snuke".
- Patty Nelson - A student at South Park Elementary.
- Peter Nelson - Randy's geologist coworker.
- Steve Nelson - A commercial producer who appears in "A Scause For Applause".
- Tammy Nelson - A student at South Park Elementary.
- Tom Nelson - A trash talking parent in "The Losing Edge".