Brian Whipple and Mrs. Whipple appear in Season 15 episode, "The Last of the Meheecans" as the couple who took in Butters, playing as Mantequilla.
Background
Butters was lost when he got separated from the others during a game of Texans vs. Mexicans. The Whipples hit Butters with their car while he is trying to find his way back to Eric Cartman's house. They took him in, gave him a place to stay, and taught him how to clean and do laundry. After Butters expressed wishes to return to his family, the Whipples dropped him off at an El Pollo Loco.
Appearance
Brian Whipple wears a light blue-gray shirt under a gray coat and khaki slacks with a red belt. He also wears black dress shoes and have combed brown hair.
Mrs. Whipple wears black high-heeled shoes, a black skirt, and a pink blouse with a blue undershirt. She has short, blonde hair and wears a conservative amount of makeup.
Personality
The Whipples were very nice to Butters, although they seem condescending and naive to who he actually is. They treat him like a servant, giving him a bottle of window cleaner and making him wash the dishes. Brian Whipple even bought him a gas powered leaf blower as a present and taught him how to use it. Not realizing that Butters is an American boy, they ignorantly take him to an El Pollo Loco restaurant to "be with his own kind."
The Whipples appear to be religious, due to the many Christian icons and slogans decorating their walls.