With Kyle suffering from kidney failure, he was recommended a surgery which worries his mother. Sharon Marsh suggested to Sheila that they try holistic natural medicine, and goes to Miss Information's New Age Shop to retrieve Native American herbs.
As Cheech and Chong enter the store, they were surrounded by patrons who were looking to buy their new products, including a "Cherokee Hair Tampon". Later as Stan began to doubt the reliability of spiritual medicine, he was reprimanded by his mom. Stan decided to take matters into his own hands in order to save his best friend: attempting to retrieve Cartman's kidney.
After trying spiritual medicine, Kyle was brought into the store for a personal appointment, looking extremely weak. It was later revealed that Cheech and Chong were not Native Americans, but actually Mexicans, and accused Miss Information for fraud, with them having to act as Native Americans under her opinion that "nobody would buy anything from Mexicans".
The store is a small purple building. The sign is framed by two antlers and its entrance is a curtain of beads. From the window next to the store displays a pyramid with an eye on one side, a crystal ball and stand, a little elephant, and some charms. Outside, under the window, is a bed of flowers.