Madonna is an American musician who is famous for songs such as "Vogue", "Like a Virgin", and "Material Girl". She appeared in the episode "Kenny Dies".
Background
When Kenny is suffering from an debilitating illness and was hospitalized, the Make A Wish Foundation arrives to grant Kenny one wish before he died. When asked what his wish would be, Kenny's responded (with Kyle translating his muffled voice), "not to die". After a moment of awkwardness, the Make A Wish people suggested that maybe he'd like to meet Madonna. Kenny however rejected this wish, calling Madonna "...an anorexic whore who wishes she was British and that she should go fuck herself."
At that moment, Madonna herself came and asked in an obviously fake British accent, if she should come in, but the Foundation decided it wasn't a good time.
Appearance
Madonna seems excessively skinny, she is possibly anorexic, as referenced by Kenny. She also has a large head, a large nose, large lips, small eyes slathered in mascara and blue eye shadow, and sunken in cheeks. She wore a white crop top with the American flag in the shape of a "2" at its center as well as white pants with what resembled the brown patches commonly seen on cows.