- For other uses, see List of Minor Characters.
- Main article: Anthropologist
The Anthropologist was seen at a field trip at the beginning of "Mecha-Streisand".
- Main article: Barbra Streisand
Barbra Streisand features prominently in "Mecha-Streisand". She tries to get the Triangle of Zinthar, which she uses to transform into Mecha-Streisand and destroy South Park. She is defeated by Leonard Maltin, Sidney Poitier, and Robert Smith.
- Main article: Bob Saget
Bob Saget appeared in "Cartman's Mom is a Dirty Slut", in which he is seen hosting "America's Stupidest Home Videos".
- Main article: Bob Johnson
- Main article: Damien Thorn
Damien Thorn is the son of Satan. In "Damien", Damien comes to the boys' class. He is taunted by the boys and turns Kenny into a duck-billed platypus before demanding to speak to Jesus. Damien's father, Satan, challenges Jesus to a boxing match, and most everyone bets their money on Satan. Satan throws the fight and Damien returns to Hell alongside his father.
- Main article: Death (Character)
Death appears physically in "Death". The four boys (along with Grandpa Marsh) encounter Death when he comes for Kenny. Grandpa Marsh also sees Death, and tries to get Death to kill him too, but Death uses the spirit of Grandpa's Grandpa to show him otherwise.
- Main article: Don King
- Main article: Enrique
- Main article: Fluffy
Fluffy is Cartman's pet pig, who the boys try to use to make pot-bellied elephants in "An Elephant Makes Love to a Pig".
- Main article: Geraldo Rivera
Geraldo Rivera was a former talk show host. He appeared in "Weight Gain 4000" on his show, where Eric Cartman was a guest.
- Main article: Hakeem Korashki
- Main article: John Warsog
John Warsog is the name of the President of Cartoon Central. His only appearance is in "Death", and his dialogue is extremely limited.
Kathie Lee Gifford
- Main article: Kathie Lee Gifford
Kathie Lee Gifford visited South Park in "Weight Gain 4000" to reward Cartman for winning the essay contest. Mr. Garrison, angry at her for beating him in a talent show when they were younger, decides to attempt to assassinate her. Despite Stan and Wendy trying to convince him not to, Mr. Garrison went forth with his plan and fired at Kathie Lee, however she survived as she was thrown off the stage when Cartman's enormous girth broke the stage.
- Main article: Kyle's Elephant
Kyle's Elephant appeared in "An Elephant Makes Love to a Pig" when Kyle tried to make pot-bellied elephants.
- Main article: Leonard Maltin
Leonard Maltin appears in "Mecha-Streisand", in which he assists Sidney Poitier and Robert Smith in defeating Barbra Streisand, all of whom can transform into Japanese movie monsters. Maltin transforms into an Ultraman-type character in order to fight Mecha-Streisand.
- Main article: Ms. Ellen
Ms. Ellen was a substitute teacher in "Tom's Rhinoplasty". Stan, along with the other boys, fell in love with her. This made Wendy Testaburger jealous and she organized a plot to get rid of her, which ended with Ms. Ellen being shot into the sun by Iraqis.
- Main article: Mutant Turkeys
The Mutant Turkeys are a group of genetically engineered turkeys that ran riot in "Starvin' Marvin".
- Main article: Patrick Duffy
- Main article: Rex
- Main article: Richard Stamos
- Main article: Robert Smith
Singer Robert Smith, a member of the band The Cure, appears in "Mecha-Streisand". He is called in to assist Leonard Maltin and Sidney Poitier in defeating Barbra Streisand, all of whom can transform into Japanese movie monsters. Smith turns himself into a giant moth and fights Mecha-Streisand with a sonic scream and "Robert Punch".
- Main article: Sally Struthers
Sally Struthers appears in "Starvin' Marvin". When Cartman is mistaken for a starving African child and send him to Ethiopia, he discovers Sally Struthers is hoarding the food donations in a small building. As the episode progresses, Sally eats more and more food and eventually becomes huge.
- Main article: Scuzzlebutt
Scuzzlebutt is a basket-weaving monster who lives on top of a mountain in South Park. He appears in "Volcano", where Cartman tells the story of Scuzzlebutt to scare his friends. Cartman then dresses up like Scuzzlebutt to further frighten the boys. However, when a volcano erupts, the real Scuzzlebutt weaves a wicker basket that saves the children. Shortly after, Stan kills Scuzzlebutt to prove to his Uncle Jimbo that he is a good nephew.
- Main article: Sidney Poitier
Sidney Poitier appears in "Mecha-Streisand", in which he assists Leonard Maltin and Robert Smith in defeating Barbra Streisand, all of whom can transform into Japanese movie monsters. Poitier transforms into a giant turtle in order to fight Mecha-Streisand, he is tossed into a mountain by her and never seen again after that, his fate is unknown.
- Main article: Sparky
Sparky is Stan Marsh's dog. He appears in "Big Gay Al's Big Gay Boat Ride" where Stan discovers that Sparky is gay and is mimicked for it. Overhearing Stan repeating an anti-gay tirade first heard from Mr. Garrison, Sparky flees to the shelter of Big Gay Al's Big Gay Animal Sanctuary. He is soon found by Stan and returned home.
- Main article: Starvin' Marvin (Character)
Starvin' Marvin is a thin little boy from Ethiopia, who first appeared in "Starvin' Marvin", where Marvin was accidentally shipped over to the boys, who then took him into their custody, and tried to teach him the ways of the Americans. But they were found out, and forced to return him to Ethiopia.
- Main article: Ted
- Main article: Unnamed Couple ("Starvin' Marvin")
The Unnamed Couple are South Park residents who were first seen in "Starvin' Marvin", though the woman has been seen earlier than that in "Pinkeye" and the man was also seen earlier than that in "Death".
- Main article: Visitors
Visitors are aliens who came to Earth and gave Eric Cartman an Anal Probe in "Cartman Gets an Anal Probe". They also kidnapped Ike and then said that cows were the most intelligent species on earth. They appear in later episodes as hidden characters.
Weight Gain 4000 Ad Actor
- Main article: Weight Gain 4000 Ad Actor
"Lava and You" Boys
- Main article: "Lava and You" Boys