The address of the building, 13280, is a play on the word "lesbo".
Allison invites a frustrated Mrs. Garrison to the bar while working out at the Curves for Women gym. Garrison, being skeptical of the bar, was not aware of what "girl bar" meant until she was told when she arrived. After Garrison confided in Allison about her confusion about lesbian sexuality, they both had sex all night.
The next day, Garrison learns that Les Bos was to be bought by Persian club owners, who wanted to remodel it with cheesy decorations. It was after a futile attempt to persuade the Mayor to forbid the transaction that Garrison vowed to do whatever was necessary to save her new favorite bar.
After an awkward confrontation with the Persian leader, Xerxes, Garrison managed to not only save Les Bos, but she was able to keep it in its existing state, a lesbian bar.
While the correct pronunciation is "Leh boh", Mrs. Garrison would instead call it "Lez bohz".