Job is a Biblical character mentioned in the Hebrews' "Literature of Wisdom" corpus of the Bible. Most scholars believe he is a fictional character created to teach the readers about morals. Job lived in the Ancient Near East and is shown in a flashback in "Cartmanland".
Kyle Broflovski pops his hemorrhoid on the barbed wire fence while waiting in line in North Park Funland which was bought by Eric Cartman, infecting the sore and almost killing him. He is taken to Hells Pass Hospital where he denounces his faith completely, and his parents' description of the trials of Job who suffered despite being a good person does little to assure him, only resulting in him believing God is even worse.