In the episode "Are You There God? It's Me, Jesus", a large crowd of people and the media wait outside Jesus' residence wondering about what Jesus will do for the year 2000. As Jesus steps out of his home, the crowd pressures him to do something extraordinary for the new millennium by pressuring him they want to see God.
His home also appears in the episode "Super Best Friends", where Stan Marsh asks Jesus about David Blaine's idea about manipulating people through religion. Jesus calls his friends from the Super Best Friends Group to put a stop to him.
Jesus' residence is built similarly to most of the other houses in South Park. It is painted dark cyan and has a detached garage.
The areas of the house that are seen are the living room, a study room, and the bedroom. The living room has a yellow-green wall, a teal floor, a purple sofa, and a television set. The study room has a desk where Jesus writes a letter to God, and a picture of Jesus and Santa Claus singing their Christmas Medley duet from Mr. Hankey's Christmas Classics. The bedroom has a purple bed and a television set as well.
- "Are You There God? It's Me, Jesus" - Debut
- "Super Best Friends" - Stan comes here to ask Jesus to stop David Blaine.
- Jesus' house number is 80122. This is also the zip code for Littleton, Colorado, where Eric Stough, one of the show's producers, grew up.