Indiana Jones appears in the episode, "The China Probrem", where he is shown being repeatedly raped by Lucas and Spielberg (a result of Indiana Jones and the Kingdom of the Crystal Skull). This is referenced again in "Pandemic" when Kyle says he could not go to Peru since "a friend was raped there". A picture of him is seen in Bradley Biggle's room in "Coon vs. Coon & Friends".
Indiana Jones appeared briefly in "Free Hat". During the premiere of Raiders of the Lost Ark, he was shown swinging across a chasm, and in another shot retrieving the headpiece treasure.
In "The China Probrem", he is shown in a brown "cowboy" hat, a nearly half-unbuttoned tan shirt, brown coat, and brownish pants. He also appears to be wearing a sack of some sort as well as a belt. In the episode "200", he is shown being held against his will in BDSM bondage gear, a ball gag, and a leash, which is held by George Lucas.