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Grandma Tweak is Tweek Tweak's grandmother. She is the mother of either Tweek's mother or father and lives with the family sometimes; her bedroom is used as an office when she is not present.


During Cartman's tour of the Tweak Residence to a group of city people, he opens the door to the bathroom, finding Tweek's grandmother who is using the toilet.


Grandma Tweak has long, curled gray hair. She wears a pink sweater decorated with daisies and roses over a white blouse and gray sweatpants, along with a pair of brown-framed glasses.

Minor Characters from Season Twenty-Five
Airsoft Armory Salesman | Blinky's Airsoft Referee | Cannabis Farmers Panelist | Coney Island Hotdog Owner | Davey Solokov | Dressage Referee | Farty O'Cool | German Band | Grandma Tweak | IHOP Customer | John Aspinal | Melancholy | Mike ("Pajama Day") | Mr. and Mrs. Billings | Mr. and Mrs. Solokov | Public Defender | Rick ("Pajama Day") | Saint Patrick | Sarah | Sergei Shoigu | Trevor | Trevor's Mother

More information: Season Twenty-Five | List of Minor Characters from Season Twenty-Five