In "Handicar", the adults of South Park go to Food 4 Little to buy cereal to eat while watching Wacky Races, but the store has run out of cereal by then.
In "The Problem with a Poo", Strong Woman and PC Principal go to Food 4 Little to buy diapers for the PC Babies, but are interrupted by several people who take notice of the babies and make them cry by saying non-PC things.
In "Christmas Snow", the adults of South Park try to buy alcohol at Food 4 Little, but find that the liquor isle has been blocked off by a chain, due to a law that prohibited alcohol from being sold temporarily.
- "Handicar" - The adults try to buy cereal here.
- "The Problem with a Poo" - PC Principal and Strong Woman shop here.
- "The Scoots" - Mr. Mackey tries to buy Halloween candy here.
- "Season Finale" - The Whites are seen in front of Food 4 Little, telling everyone to support Tegridy Farms.
- "Turd Burglars" - Sheila shops here.
- "Basic Cable" - Clark Malkinson shops here.
- "Christmas Snow" - The adults try to buy alcohol here.
- "The Pandemic Special" - A panic-buying took place here.
- Food 4 Little is based on the real life chain of grocery stores called Food 4 Less, though there are currently none in Colorado.