Charlie Brown in South Park is almost identical to his original design. He wears a yellow shirt with a black stripe, black shorts, white socks, and brown shoes. He's almost bald, with only a small curl of hair in front of his head. Unlike the Family Guy characters in the "Cartoon Wars Part I" and "Cartoon Wars Part II" episodes, Charlie Brown has the eyes and the same mouth shapes of a normal South Park character and has no black outline.
- "A Very Crappy Christmas" - Debut; The Boys watch Peanuts on TV and have the idea of making a short Christmas film to cheer up the citizens.
- "Imaginationland" - He is killed by the bomb explosion and loses his left leg.
- "Imaginationland, Episode III" - He is revived along with the other Imaginationland creatures at the end of the episode.