These episodes contain celebrity appearances where a guest voice actor plays a role or themselves.
- Numerous episodes - Issac Hayes voices Chef
- Cartman Gets an Anal Probe - Franchesca Clifford voices Ike Broflovski
- Weight Gain 4000 - Karri Turner voices Kathie Lee Gifford
- Big Gay Al's Big Gay Boat Ride - George Clooney voices Sparky
- An Elephant Makes Love to a Pig - Frank Welker voices Various Animals
- Pinkeye - Jennifer Howell voices Bebe Stevens
- Starvin' Marvin - Jesse Howell voices Ike Broflovski
- Mr. Hankey, the Christmas Poo - Jesse Howell voices Ike Broflovski
- Damien - Michael Buffer voices himself
- Tom's Rhinoplasty - The Chick From Species voices Ms. Ellen
- Mecha-Streisand - Robert Smith of The Cure voices himself
- Cartman's Mom is a Dirty Slut - Jay Leno voices Mr. Kitty
- City on the Edge of Forever (Flashbacks) - Brent Musberger voices himself as Scuzzlebutt's leg
- City on the Edge of Forever (Flashbacks) - Henry Winkler voices Big Black Scary Monster
- City on the Edge of Forever (Flashbacks) - Jay Leno voices himself
- Summer Sucks - Jonathan Katz voices his character of the same name, from Dr. Katz, Professional Therapist
- Chef Aid - Joe Strummer performing as himself
- Chef Aid - Tim Armstrong, Lars Fredriksen, Matt Freeman, and Brett Reed performing as themselves as their band, Rancid.
- Chef Aid - Ozzy Osbourne, DMX, and Ol' Dirty Bastard performing as themselves
- Chef Aid - Mickey Melchiondo and Aaron Freeman performing as their band, Ween
- Chef Aid - Les Claypool, Larry LaLonde, and Bryan Mantia performing as their band, PRIMUS
- Chef Aid - Sir Elton John performing as himself
- Chef Aid - Marvin Lee Aday performing as himself, Meatloaf
- Chef Aid - Rick James performing as himself
- Rainforest Shmainforest - Jennifer Aniston voices Ms. Stevens
- Korn's Groovy Pirate Ghost Mystery - Jonathan Davis, James Shaffer, Reginald Arvizu, David Silveria, and Brian Welch voice themselves, as their band, Korn
- The Tooth Fairy Tats 2000 - Richard Belzer voices Loogie
- Cherokee Hair Tampons - Cheech Marin and Tommy Chong voice their characters Cheech and Chong, as "Carlos Ramirez" and "Chief Running Pinto" respectively
- Pip - Malcolm McDowell voices himself, as a British Person
- Scott Tenorman Must Die - Thom Yorke, Jonny Greenwood, Ed O'Brien, Colin Greenwood, and Phil Selway voice themselves, as their band, Radiohead
- Towelie - Mark Antony Krupa voices Tynacorp leader
- I'm a Little Bit Country - Norman Lear voices Benjamin Franklin
- Red Man's Greed - Alex Glick voices himself as Alex Glick, winner of the guest role charity auction
- The Jeffersons - Dante Alexander voices Blanket Jackson
- Pre-School - Dante Alexander voices Young Stan Marsh Others??
- Wing - Wing Han Tsang performs as herself
- The Return of Chef - Peter Serafinowicz voices Darth Chef
- Cartman Finds Love - Brad Paisley performing as himself
- The Cissy - Sia performing as Randy Marsh performing as Lorde
- #REHASH - Felix Kjellberg performing as himself, as PewDiePie
- #HappyHolograms - Felix Kjellberg performing as himself, as PewDiePie
- Members Only - Elon Musk voices himself
- Not Funny - Elon Musk voices himself
- The End of Serialization as We Know It - Elon Musk voices himself
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- Terrance and Phillip: Behind the Blow
- The Biggest Douche in the Universe
- The China Probrem
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- The Entity
- The F Word
- The Jeffersons
- The New Terrance and Phillip Movie Trailer
- The Passion of the J—
- The Ring
- The Tale of Scrotie McBoogerballs
- The Tooth Fairy Tats 2000
- Timmy 2000
- Tonsil Trouble
- Towelie
- Trapped in the Closet
- Tsst