The band was one of several musical celebrities that joined the boys' band, Moop, in their strike against illegal music downloading.
Although this is their only appearance as a group, they were mentioned in the episode "The Snuke", when the boys are finding information about the new student, Baahir Hassan Abdul Hakeem. Hakeem's MySpace profile states that his favorite band is The White Stripes, while he told everyone in class that his favorite band was Blink-182. This leads Cartman to conclude that Baahir was lying, and thus likely to be a terrorist.
They are again referenced a few episodes later in "Le Petit Tourette" when Thomas uses the "CuteBilly182" moniker to attract older men to the Dateline Studio.