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Big Vape Colorado appeared in Season Twenty-Two episode "Tegridy Farms". It is a vaping shop where customers can both buy and smoke electronic cigarettes.

The layout is purposefully similar to the Medicinal Fried Chicken and some of the staff is the same. The connection to the sale of marijuana is furthered with the street dealer who makes his purchase there. The building and upstairs factory are destroyed when Randy beats up the patrons then overloads the vats.

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