Apple HQ is the base for Apple Inc. that was featured in the Season Fifteen episode "HUMANCENTiPAD".
Background
Steve Jobs gathers some of Apple's employees unveils their new product, the HUMANCENTiPAD, which consists of Kyle Broflovski being sewn together with a Japanese man and a Caucasian woman. However, he became disappointed when Kyle continued to sign agreements without reading it first. Steve then fed the Japanese man a burrito, would who in turn defecate into Kyle's mouth, and into the woman's mouth as well.
At night, when the HUMANCENTiPAD was left caged, Steve Jobs devised another simulation where a group of armed men would "rescue" the product and evacuate them to a hospital. The simulation eventually failed with Kyle signing an agreement without reading once more.