In "Jared Has Aides", Jared Fogle said he had 'aides' (a personal trainer and dietitian), and he wanted to give everyone aides as well. Unfortunately, everyone thought he meant the disease, thereby ruining his reputation and almost getting him hanged. He was saved when the boys cleared up the confusion between his 'aides' and AIDS, causing everyone to laugh about misunderstanding him. Because of that, they declared that AIDS is finally funny after 22.3 years.
More than once, Cartman has joked about or suggested giving Kyle AIDS. In "Casa Bonita" Kyle walked into Stan's house where the other boys were. He says he has good news and Cartman says, "You have AIDS?" In "Cartman Joins NAMBLA", the boys were playing a game, and Cartman used a card and said he gave Kyle AIDS. In "Red Man's Greed", Eric Cartman suggests infecting Kyle Broflovski with AIDS to raise money, through charity, to buy South Park back from the Native Americans. In "Woodland Critter Christmas" the end of Cartman's story goes, "They all lived happily ever after... except for Kyle, who died of AIDS two weeks later."
In "Tonsil Trouble", Eric Cartman contracted AIDS from a failed blood transfusion and then gave it to Kyle Broflovski via a needle. They found a cure for it, that cure being "about $180,000" of "highly-concentrated" cash shot directly into the bloodstream.
In "The Death of Eric Cartman", Mr. Stotch tells Butters that he should be afraid of real things, like "super AIDS". He says it is "a new form of AIDS which is resistant to drugs," and claims that "just one teaspoon of super AIDS in your butt and you're dead in three years."
- "Jared Has Aides"
- "Red Sleigh Down"
- "Red Man's Greed"
- "Woodland Critter Christmas"
- "Imaginationland, Episode II"
- "Tonsil Trouble"