Cartman reacts when he meet Lucifer
Lucifer reacts when he meet Cartman
Cartman reacts when he meet Lucifer
Lucifer reacts when he meet Cartman
Wendy and Heidi (my personal favorite duo) I know they don't have dialogue each other but I want to headcanon their relationship was like.
Stan and Kyle (later seasons of their friendship)
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Guitar Queer-O
Kyle: I don't need you
Stan: But I need you
South Park vaccination
Kyle: I need you
Stan: I don't need you anymore
26 Votes in Poll