Seen as we're now meant to be fairly close to a new episode being released, with it being estimated around June time I suppose it would be an appropriate time to start betting on what will be content within it.
First of all, I have little to no doubt that something related to the gas shortage will be covered. This is something which is likely because of how it would likely lead to some crazy events. Probably involving their parents.
Second, this is 50/50 but I feel as if something about the concurrent trend being something negative Mr Garrison. This will likely exist in the form of blood clots, whereby the population of South Park will be blaming him specifically about how they would get in. This would also link back to the Covid theme of the season.
I also suspect that they will likely try to quickly wrap up the Kenny arc with how they were friends with him. However, this is something which is also 50/50 as there are cases of things being forgotten in the season, eg the mustaches with the vaccination special but there are also cases of large things revolving Kenny being carried over. The most notable of this is where Kenny was killed off for essentially just over a season.