In the Vax Special, Stan, Kyle and Cartman had a falling out, and Cartman got new buddies: Clyde, the Hispanic dude and Jimmy. For the next episode, I see this picking up where it left off, with Stan and Kyle both getting new friends too. While I see this being temporary, I also think it'll last a full season, as part of experimenting from Matt & Trey. Anyway, my picks for Stan and Kyle's new bros are:
Stan's group: Scott Malkinson, Bradley Biggle and Craig Tucker
Kyle's group: Tweek Tweak, Token Black and Kevin Stoley
For the first 2 episodes, I see the Kenny 2-2-3 format in effect. Throughout that time, he gets along with each of the gang members. At first all three of the groups work out great, with Cartman's group being the chummiest. However, by the episode after Kenny begins to wonder why the three boys don't hang anymore, and Kyle is forced to reveal the truth. Kenny asks Cartman if it's true what Kyle said, and he confirms it. To add insult to injury, he reveals that he's much happier with his new bros and rants about how horribly Stan and Kyle treated him over the years. Shocked and heartbroken, Kenny walks out on all three. He begins hanging with Butters regularly, who sympathizes with him as they both get used as puppets pretty much.
A few episodes pass, Cartman's group is still pretty chummy, and his buddies are far more tolerant of him than. Kyle's group has found their new scapegoat, which is Kevin Stoley, who gets blamed for all of Kyle, Tweek and Token's antics. Token also picks up Cartman's habits of saying "Kevin goddammit" when Kevin ruins the moment. Stan's group on the other hand becomes more dysfunctional. While he's still fond of Bradley despite his childish personality, he sees Scott as a complete bore and Craig as apathetic and rude. Craig also hates Stan and Bradley too, Scott doesn't like Craig either. Bradley though has fun in the group, and amuses Stan and Scott often, sometimes Craig too, but most of the time he gets on Craig's nerves.
A few episodes after, Kenny - with the help of Butters and Wendy - apologizes to the Stan, Kyle and Cartman individually for overreacting when the news broke out, and announced he respects the decision, and would like to become buddies with each of the three, regardless if they've separated or not. They all agree, though Kenny mostly hangs with Stan's group, as no one hates him there. In the second-to-last episode, Kevin reaches his breaking point and walks out of Kyle's group, stating that he's tired of being framed of it all and that they can't respect his obsessions. Tweek backs out too because of paranoia that Kevin will snitch on his actions, and the group disbands. Kyle reconciliates with Stan, and begins hanging with him and Stan's gang regularly (Token does too temporarily). Stan's gang soon disbands too, though Bradley is kept as a close separate friend. Scott and Craig are also told the harsh truth by Stan, and while Scott takes it to heart, Craig disregards it, and reunites with Tweek and Token. Butters comforts Scott, telling him he knows how it feels to get kicked out for being lame and tells him that he's always welcome to join the Chaos gang.
Heading into the season finale, Cartman's group is the last one intact. Kyle, who's revealed to have overheard Cartman's rant to Kenny a few episodes prior, wants him back, stating that while Cartman hasn't exactly been the best guy to him, he's always been the funny one in the group and maybe they've been too harsh on him. Cartman though refuses, which then has Kyle and Kenny take other measures, including spreading false rumors to both Clyde and Cartman that one's been talking shit about the other, which ignites a feud. Jimmy and the Latino kid though, suspect something's wrong, and Jimmy eventually catches Kyle in the act, and confronts him, saying that if he wants Cartman back he can talk to him personally, and that you can have more than one friend group at a time. With this, Kyle has Stan and his girlfriend Wendy (they're revealed to be back together) talk him into rejoining the circle, and that he doesn't have to give up his old friend group. Cartman agrees, and Jimmy supports his decision. In order for celebration, Clyde invites the crew, and also Cartman's old bros, in to Casa Bonita again to celebrate which they all agree, and the episode ends with photos of the boys having fun in the restaurant, but the party gets spoiled by Stan's dad, Towelie and the other parents high on Tegridy weed, which becomes too much for police to handle.
Post S24, Cartman's New Bros are seen together occasionally (once or twice per season), but season 25 would see the fall of Tegridy Farms, as well as a Christmas and New Year special, and a Valentine's episode.