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Clyde Donovan is one of the boys' classmates and he made his debut appearance in "Cartman Gets an Anal Probe". His first speaking role was in "Weight Gain 4000"; he is voiced by Trey Parker.

In "Mystery of the Urinal Deuce", Clyde's parent inform Mr. Mackey that Clyde had a colostomy at age 5. In the Superheroes Arc, Clyde is shown to have a superhero alter-ego called "Mosquito".

In "Crack Baby Athletic Association" it is revealed that Clyde's mother is Dutch, and as such, Clyde has some Dutch ancestry. In "Reverse Cowgirl", Clyde's mother dies, due to Clyde neglecting to leave the toilet seat down. It was also in this episode where it is revealed that Clyde has a sister. (read more...)