San Francisco

 San Francisco is first seen in the Season 10 episode Smug Alert. It is shown to be the smuggiest city in America because every one in San Francisco drives Hybrids which are the leading cause of smug. Cartman's opinion on San Francisco is that everyone in San Francisco is a hippie. Then because Gerald believes that everyone in South Park is ignorant so he and his family move to San Francisco but tell Stan that they might return if he can convince the people of South Park to drive Hybrids. Which he promptly does. Which promptly creates a giant problem. A huge cloud of smug is created by the people of South Park and the people of San Francisco. He is then told that South Park might have a chance of survival but San Francisco doesn't have a snowball's chance in hell. The episode ends with the total destruction of San Francisco and some damage to South Park.